Discretizing Three-Dimensional Oxygen Gradients to Modulate and Investigate Cellular Processes.
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ABSTRACT: With the increased realization of the effect of oxygen (O2 ) deprivation (hypoxia) on cellular processes, recent efforts have focused on the development of engineered systems to control O2 concentrations and establish biomimetic O2 gradients to study and manipulate cellular behavior. Nonetheless, O2 gradients present in 3D engineered platforms result in diverse cell behavior across the O2 gradient, making it difficult to identify and study O2 sensitive signaling pathways. Using a layer-by-layer assembled O2 -controllable hydrogel, the authors precisely control O2 concentrations and study uniform cell behavior in discretized O2 gradients, then recapitulate the dynamics of cluster-based vasculo
SUBMITTER: Blatchley MR
PROVIDER: S-EPMC8292886 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
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