Cord blood group 2 innate lymphoid cells are associated with lung function at 6 weeks of age.

ABSTRACT:

Objective

Offspring born to mothers with asthma in pregnancy are known to have lower lung function which tracks with age. Human group 2 innate lymphoid cells (ILC2) accumulate in foetal lungs, at 10-fold higher levels compared to adult lungs. However, there are no data on foetal ILC2 numbers and the association with respiratory health outcomes such as lung function in early life. We aimed to investigate cord blood immune cell populations from babies born to mothers with asthma in pregnancy.

Methods

Cord blood from babies born to asthmatic mothers was collected, and cells were stained in whole cord blood. Analyses were done using traditional gating approaches and computational methodologies (t-distributed stochastic neighbour embedding and PhenoGraph algorithms). At 6 weeks o

SUBMITTER: Martins Costa Gomes G 

PROVIDER: S-EPMC8292948 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature