A Collagen-Mimetic Organic-Inorganic Hydrogel for Cartilage Engineering.

ABSTRACT: Promising strategies for cartilage regeneration rely on the encapsulation of mesenchymal stromal cells (MSCs) in a hydrogel followed by an injection into the injured joint. Preclinical and clinical data using MSCs embedded in a collagen gel have demonstrated improvements in patients with focal lesions and osteoarthritis. However, an improvement is often observed in the short or medium term due to the loss of the chondrocyte capacity to produce the correct extracellular matrix and to respond to mechanical stimulation. Developing novel biomimetic materials with better chondroconductive and mechanical properties is still a challenge for cartilage engineering. Herein, we have designed a biomimetic chemical hydrogel based on silylated collagen-mimetic synthetic peptides having the ability to en

SUBMITTER: Valot L 

PROVIDER: S-EPMC8293055 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature