Neuronal Growth and Formation of Neuron Networks on Directional Surfaces.

ABSTRACT: The formation of neuron networks is a process of fundamental importance for understanding the development of the nervous system and for creating biomimetic devices for tissue engineering and neural repair. The basic process that controls the network formation is the growth of an axon from the cell body and its extension towards target neurons. Axonal growth is directed by environmental stimuli that include intercellular interactions, biochemical cues, and the mechanical and geometrical properties of the growth substrate. Despite significant recent progress, the steering of the growing axon remains poorly understood. In this paper, we develop a model of axonal motility, which incorporates substrate-geometry sensing. We combine experimental data with theoretical analysis to measure the param

SUBMITTER: Yurchenko I 

PROVIDER: S-EPMC8293217 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature