Prospective study of polygenic risk, protective factors, and incident depression following combat deployment in US Army soldiers.

ABSTRACT:

Background

Whereas genetic susceptibility increases the risk for major depressive disorder (MDD), non-genetic protective factors may mitigate this risk. In a large-scale prospective study of US Army soldiers, we examined whether trait resilience and/or unit cohesion could protect against the onset of MDD following combat deployment, even in soldiers at high polygenic risk.

Methods

Data were analyzed from 3079 soldiers of European ancestry assessed before and after their deployment to Afghanistan. Incident MDD was defined as no MDD episode at pre-deployment, followed by a MDD episode following deployment. Polygenic risk scores were constructed from a large-scale genome-wide association study of major depression. We first examined the main effects of the MDD PRS and each prote

SUBMITTER: Choi KW 

PROVIDER: S-EPMC8293300 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature