Cenobamate, a Sodium Channel Inhibitor and Positive Allosteric Modulator of GABA_A Ion Channels, for Partial Onset Seizures in Adults: A Comprehensive Review and Clinical Implications.

ABSTRACT: Medical management of epilepsy seeks to eliminate or to reduce the frequency of seizures, help patients maintain a normal lifestyle, and maintain psychosocial and occupational activities, while avoiding the negative side effects of long-term treatment. Current FDA approved drugs have been shown to have similar efficacy; however, they all share a commonality of having side effects that have the potential to significantly reduce a patient's quality of life. Cenobamate, a newly-FDA approved drug used to treat partial-onset seizures in adult patients, has demonstrated promise in that it works on two proposed mechanisms that are commonly associated with epilepsy. Cenobamate acts as a positive allosteric modulator of the GABA_A ion channels and is effective in reducing repetitive neuro

SUBMITTER: Latimer DR 

PROVIDER: S-EPMC8293325 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature