Downregulation of Salivary Proteins, Protective against Dental Caries, in Type 1 Diabetes.

ABSTRACT: Saliva, an essential oral secretion involved in protecting the oral cavity's hard and soft tissues, is readily available and straightforward to collect. Recent studies have analyzed the salivary proteome in children and adolescents with extensive carious lesions to identify diagnostic and prognostic biomarkers. The current study aimed to investigate saliva's diagnostic ability through proteomics to detect the potential differential expression of proteins specific for the occurrence of carious lesions. For this study, we performed bioinformatics and functional analysis of proteomic datasets, previously examined by our group, from samples of adolescents with regulated and unregulated type 1 diabetes, as they compare with healthy controls. Among the differentially expressed proteins relevant

SUBMITTER: Pappa E 

PROVIDER: S-EPMC8293329 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature