A Rapid Review on the Efficacy and Safety of Pharmacological Treatments for Chagas Disease.

ABSTRACT: Chagas disease remains a neglected tropical disease, causing significant burden in the Americas and countries that receive immigrants from endemic nations. Current pharmaceutical treatments are suboptimal, not only varying drastically in efficacy, depending on the stage of disease, but also presenting significant risk of adverse events. The objective of this review is to provide a timely update on the efficacy and safety of current trypanocidals. Eligible studies published from January 2015 to December 2020 were retrieved by one reviewer from six electronic databases. Ana-lysis was done with review management software and risk of bias was assessed using tools appropriate for the type of study (i.e., experimental or observational). Thirteen studies (10 observational and three RCTs) were inc

SUBMITTER: Malone CJ 

PROVIDER: S-EPMC8293415 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature