The informed road map to prevention of Alzheimer Disease: A call to arms.

ABSTRACT: Alzheimer disease (AD) prevention trials hold the promise to delay or prevent cognitive decline and dementia onset by intervening before significant neuronal damage occurs. In recent years, the first AD prevention trials have launched and are yielding important findings on the biology of targeting asymptomatic AD pathology. However, there are limitations that impact the design of these prevention trials, including the translation of animal models that recapitulate key stages and multiple pathological aspects of the human disease, missing target validation in asymptomatic disease, uncertain causality of the association of pathophysiologic changes with cognitive and clinical symptoms, and limited biomarker validation for novel targets. The field is accelerating advancements in key areas incl

SUBMITTER: McDade E 

PROVIDER: S-EPMC8293489 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature