Circulating miR-146a as a possible candidate biomarker in the indeterminate phase of Chagas disease.

ABSTRACT:

Background

Chagas disease is considered important and presents intense inflammatory and fibrotic processes induced by the perpetuation of the parasite in the affected tissues and organs. Therefore, it is necessary to inquire about the host defense and attack mechanisms to have a more detailed knowledge about Chagas disease. MicroRNAs are found in blood, tissues and extracellular vesicles. These small regulators of gene expression are involved in physiological and pathological processes in both mammals and parasites. Several microRNAs have deregulated expression in chagasic heart disease, although little is known about their extracellular expression. Our main objective was to evaluate the involvement of miR-21, miR-146a and miR-155 in several samples from mice infected with the TcI

SUBMITTER: Ballinas-Verdugo MA 

PROVIDER: S-EPMC8293491 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature