Weight shapes the intestinal microbiome in preterm infants: results of a prospective observational study.

ABSTRACT:

Background

The intestinal microbiome in preterm infants differs markedly from term infants. It is unclear whether the microbiome develops over time according to infant specific factors.

Methods

We analysed (clinical) metadata - to identify the main factors influencing the microbiome composition development - and the first meconium and faecal samples til the 4th week via 16 S rRNA amplican sequencing.

Results

We included 41 infants (gestational age 25-30 weeks; birth weight 430-990 g. Birth via Caesarean section (CS) was associated with placental insufficiency during pregnancy and lower BW. In meconium samples and in samples from weeks 2 and 3 the abundance of Escherichia and Bacteroides (maternal faecal representatives) were associated with vaginal delivery while Stap

SUBMITTER: Heida FH 

PROVIDER: S-EPMC8293572 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature