Identification of novel antioxidant gene signature to predict the prognosis of patients with gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) commonly relates to dismal prognosis and lacks efficient biomarkers. This study aimed to establish an antioxidant-related gene signature and a comprehensive nomogram to explore novel biomarkers and predict GC prognosis.

Methods

Clinical and expression data of GC patients were extracted from The Cancer Genome Atlas database. Univariate and multivariate Cox analyses were utilized to construct a score-based gene signature and survival analyses were conducted between high- and low-risk groups. Furthermore, we established a prognostic nomogram integrating clinical variables and antioxidant-related gene signature. Its predictive ability was validated by Harrell' concordance index and calibration curves and an independent internal cohort verified the

SUBMITTER: Wu J 

PROVIDER: S-EPMC8293592 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature