Cortical Thickness and Its Association with Clinical Cognitive and Neuroimaging Markers in Cerebral Amyloid Angiopathy.

ABSTRACT:

Background

Cerebral amyloid angiopathy (CAA) contributes to brain neurodegeneration and cognitive decline, but the relationship between these two processes is incompletely understood.

Objective

The purpose of this study is to examine cortical thickness and its association with cognition and neurodegenerative biomarkers in CAA.

Methods

Data were collected from the Functional Assessment of Vascular Reactivity study and the Calgary Normative Study. In total, 48 participants with probable CAA, 72 cognitively normal healthy controls, and 24 participants with mild dementia due to AD were included. Participants underwent an MRI scan, after which global and regional cortical thickness measurements were obtained using FreeSurfer. General linear models, adjusted for age and sex

SUBMITTER: Subotic A 

PROVIDER: S-EPMC8293635 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature