Language Network Connectivity Increases in Early Alzheimer's Disease.

ABSTRACT:

Background

Language production deficits occur early in the course of Alzheimer's disease (AD); however, only a few studies have focused on language network's functional connectivity in mild cognitive impairment (MCI) due to AD.

Objective

The current study aims to uncover the extent of language alteration at the MCI stage, at a behavioral and neural level, using univariate and multivariate analyses of structural MRI and resting-state fMRI.

Methods

Twenty-four MCI due to AD participants and 24 matched healthy controls underwent a comprehensive language evaluation, a structural T1-3D MRI, and resting-state fMRI. We performed seed-based analyses, using the left inferior frontal gyrus and left posterior temporal gyrus as seeds. Then, we analyzed connectivity between execut

SUBMITTER: Pistono A 

PROVIDER: S-EPMC8293644 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature