Blood DNA Methylation Levels in the WNT5A Gene Promoter Region: A Potential Biomarker for Agitation in Subjects with Dementia.

ABSTRACT:

Background

Behavioral and psychological symptoms of dementia (BPSD) cause a heavy burden for both patient and caregivers. These symptoms are diverse, and their mechanism is still unclear. Agitation is the most common and difficult to treat among BPSD. In recent years, while changes in DNA methylation levels have been receiving attention as a biomarker of aging and dementia, associations with BPSD have not been examined.

Objective

Focusing on agitation, the objective of the present study was to identify a region where changes in DNA methylation levels are associated with agitation.

Methods

Using genome-wide DNA methylation analysis data for 7 dementia subjects with agitation, 5 dementia subjects without agitation, and 4 normal elderly controls, we determined a signalin

SUBMITTER: Kobayashi N 

PROVIDER: S-EPMC8293647 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature