Dataset Information

Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer's Disease.

ABSTRACT:

Background

The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), and 211 with Alzheimer's disease dementia (AD)) as an 'Inception cohort' who underwent detailed ssessments every 18 months. Over the past decade, an additional 1247 subjects have been added as an 'Enrichment cohort' (as of 10 April 2019).

Objective

Here we provide an overview of these Inception and Enrichment cohorts of more than 8,500 person-years of investigation.

Methods

Participants underwent reassessment every 18 months including comprehensive cognitive testing, neuroimaging (magnetic resonance imaging, MRI; positron emission tomography, PET), biofluid biomarkers and lifestyle evaluations.

Results

AIBL has made major contributions to the understanding of the natural history of AD, with cognitive and biological definitions of its three major stages: preclinical, prodromal and clinical. Early deployment of Aβ-amyloid and tau molecular PET imaging and the development of more sensitive and specific blood tests have facilitated the assessment of genetic and environmental factors which affect age at onset and rates of progression.

Conclusion

This fifteen-year study provides a large database of highly characterized individuals with longitudinal cognitive, imaging and lifestyle data and biofluid collections, to aid in the development of interventions to delay onset, prevent or treat AD. Harmonization with similar large longitudinal cohort studies is underway to further these aims.

SUBMITTER: Fowler C

PROVIDER: S-EPMC8293663 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer's Disease.

Fowler Christopher C Rainey-Smith Stephanie R SR Bird Sabine S Bomke Julia J Bourgeat Pierrick P Brown Belinda M BM Burnham Samantha C SC Bush Ashley I AI Chadunow Carolyn C Collins Steven S Doecke James J Doré Vincent V Ellis Kathryn A KA Evered Lis L Fazlollahi Amir A Fripp Jurgen J Gardener Samantha L SL Gibson Simon S Grenfell Robert R Harrison Elise E Head Richard R Jin Liang L Kamer Adrian A Lamb Fiona F Lautenschlager Nicola T NT Laws Simon M SM Li Qiao-Xin QX Lim Lucy L Lim Yen Ying YY Louey Andrea A Macaulay S Lance SL Mackintosh Lucy L Martins Ralph N RN Maruff Paul P Masters Colin L CL McBride Simon S Milicic Lidija L Peretti Madeline M Pertile Kelly K Porter Tenielle T Radler Morgan M Rembach Alan A Robertson Joanne J Rodrigues Mark M Rowe Christopher C CC Rumble Rebecca R Salvado Olivier O Savage Greg G Silbert Brendan B Soh Magdalene M Sohrabi Hamid R HR Taddei Kevin K Taddei Tania T Thai Christine C Trounson Brett B Tyrrell Regan R Vacher Michael M Varghese Shiji S Villemagne Victor L VL Weinborn Michael M Woodward Michael M Xia Ying Y Ames David D

Journal of Alzheimer's disease reports 20210603 1

<h4>Background</h4>The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), and 211 with Alzheimer's disease dementia (AD)) as an 'Inception cohort' who underwent detailed ssessments every 18 months. Over the past decade, an additional 1247 subjects have been added as an 'Enrichment cohort' (as of 10 April 2019).<h4>Objective</h4>Here we provide an overview o ...[more]

PMID: 34368630

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Dataset Information

Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer's Disease.

Background

Objective

Methods

Results

Conclusion

Publications

Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer's Disease.

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