A High-Denticity Chelator Based on Desferrioxamine for Enhanced Coordination of Zirconium-89.

ABSTRACT: Herein we report a new high-denticity chelator based on the iron siderophore desferrioxamine (DFO). Our new chelator-DFO2-is acyclic and was designed and synthesized with the purpose of improving the coordination chemistry and radiolabeling performance with radioactive zirconium-89. The radionuclide zirconium-89 ([⁸⁹Zr]Zr⁴⁺) has found wide use for positron emission tomography (PET) imaging when it is coupled with proteins, antibodies, and nanoparticles. DFO2 has a potential coordination number of 12, which uniquely positions this chelator for binding large, high-valent, and oxophilic metal ions. Following synthesis of the DFO2 chelator and the [^natZr]Zr-(DFO2) complex we performed density functional theory calculations to study its coordination sphere, foll

SUBMITTER: Sarbisheh EK 

PROVIDER: S-EPMC8293797 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature