Sample-specific perturbation of gene interactions identifies breast cancer subtypes.

ABSTRACT: Breast cancer is a highly heterogeneous disease, and there are many forms of categorization for breast cancer based on gene expression profiles. Gene expression profiles are variables and may show differences if measured at different time points or under different conditions. In contrast, biological networks are relatively stable over time and under different conditions. In this study, we used a gene interaction network from a new point of view to explore the subtypes of breast cancer based on individual-specific edge perturbations measured by relative gene expression value. Our study reveals that there are four breast cancer subtypes based on gene interaction perturbations at the individual level. The new network-based subtypes of breast cancer show strong heterogeneity in prognosis, soma

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8293822 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature