The perplexing role of RAGE in pulmonary fibrosis: causality or casualty?

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease in which most patients die within 3 years of diagnosis. With an unknown etiology, IPF results in progressive fibrosis of the lung parenchyma, diminishing normal lung function, which results in respiratory failure, and eventually, death. While few therapies are available to reduce disease progression, patients continue to advance toward respiratory failure, leaving lung transplantation the only viable option for survival. As incidence and mortality rates steadily increase, the need for novel therapeutics is imperative. The receptor for advanced glycation endproducts (RAGE) is most highly expressed in the lungs and plays a significant role in a number of chronic lung diseases. RAGE has long been linked to IPF; howeve

SUBMITTER: Perkins TN 

PROVIDER: S-EPMC8293846 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature