Different DOACs Control Inflammation in Cardiac Ischemia-Reperfusion Differently.

ABSTRACT:

Rationale

While thrombin is the key protease in thrombus formation, other coagulation proteases, such as fXa (factor Xa) or aPC (activated protein C), independently modulate intracellular signaling via partially distinct receptors.

Objectives

To study the differential effects of fXa or fIIa (factor IIa) inhibition on gene expression and inflammation in myocardial ischemia-reperfusion injury.

Methods and results

Mice were treated with a direct fIIa inhibitor (fIIai) or direct fXa inhibitor (fXai) at doses that induced comparable anticoagulant effects ex vivo and in vivo (tail-bleeding assay and FeCl₃-induced thrombosis). Myocardial ischemia-reperfusion injury was induced via left anterior descending ligation. We determined infarct size and in vivo aPC genera

SUBMITTER: Gadi I 

PROVIDER: S-EPMC8293866 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature