Strategic engineering of alkyl spacer length for a pH-tolerant lysosome marker and dual organelle localization.

ABSTRACT: Long-term visualization of lysosomal properties is extremely crucial to evaluate diseases related to their dysfunction. However, many of the reported lysotrackers are less conducive to imaging lysosomes precisely because they suffer from fluorescence quenching and other inherent drawbacks such as pH-sensitivity, polarity insensitivity, water insolubility, slow diffusibility, and poor photostability. To overcome these limitations, we have utilized an alkyl chain length engineering strategy and synthesized a series of lysosome targeting fluorescent derivatives namely NIMCs by attaching a morpholine moiety at the peri position of the 1,8-naphthalimide (NI) ring through varying alkyl spacers between morpholine and 1,8-naphthalimide. The structural and optical properties of the sy

SUBMITTER: Biswas S 

PROVIDER: S-EPMC8293980 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature