The Effect of Immunosuppressive Adjuvant Kynurenine on Type 1 Diabetes Vaccine.

ABSTRACT: Inducing antigen-specific tolerance is a promising treatment for preventing or reversing Type 1 diabetes (T1D). In contrast to a vaccine that induces immune responses against pathogens, a tolerogenic vaccine can suppress immunity against antigens causing diseases by administrating a mixture of self-antigens with an adjuvant that decreases the strength of antigen-specific response. Kynurenine (Kyn) is an endogenous substance that can inhibit the natural killer cell and T cell proliferation and promote the differentiation of naïve T cells into regulatory T cells (T_regs). In this study, we evaluated the efficacy of Kyn as a novel suppressive adjuvant. Kyn was co-immunized with GAD65 phage vaccine to induce T_reg cells and tolerogenic responses for the prevention of T1D in

SUBMITTER: Sun J 

PROVIDER: S-EPMC8293994 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature