Hemodynamics in aneurysm blebs with different wall characteristics.

ABSTRACT:

Background

Blebs are important secondary structures of intracranial aneurysms associated with increased rupture risk and can affect local wall stress and hemodynamics. Mechanisms of bleb development and evolution are not clearly understood. We investigate the relationship between blebs with different wall characteristics and local hemodynamics and rupture sites.

Methods

Blebs with different wall appearances in intra-operative videos were analyzed with image-based computational fluid dynamics. Thin red blebs were compared against thick atherosclerotic/hyperplastic white/yellow blebs. Rupture points were identified in videos of ruptured aneurysms harboring blebs.

Results

Thin blebs tended to be closer to the inflow than atherosclerotic blebs of the same aneurysm (P=0.02

SUBMITTER: Salimi Ashkezari SF 

PROVIDER: S-EPMC8294199 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature