Associations between plasma nucleoside reverse transcriptase inhibitors concentrations and cognitive function in people with HIV.

ABSTRACT:

Objectives

To investigate the associations of plasma lamivudine (3TC), abacavir (ABC), emtricitabine (FTC) and tenofovir (TFV) concentrations with cognitive function in a cohort of treated people with HIV (PWH).

Methods

Pharmacokinetics (PK) and cognitive function (Cogstate, six domains) data were obtained from PWH recruited in the POPPY study on either 3TC/ABC or FTC/tenofovir disoproxil fumarate (TDF)-containing regimens. Association between PK parameters (AUC0-24: area under the concentration-time curve over 24 hours, Cmax: maximum concentration and Ctrough: trough concentration) and cognitive scores (standardized into z-scores) were evaluated using rank regression adjusting for potential confounders.

Results

Median (IQR) global cognitive z-scores in the 83 PWH on

SUBMITTER: De Francesco D 

PROVIDER: S-EPMC8294567 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature