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Place-cell capacity and volatility with grid-like inputs.

ABSTRACT: What factors constrain the arrangement of the multiple fields of a place cell? By modeling place cells as perceptrons that act on multiscale periodic grid-cell inputs, we analytically enumerate a place cell's repertoire - how many field arrangements it can realize without external cues while its grid inputs are unique - and derive its capacity - the spatial range over which it can achieve any field arrangement. We show that the repertoire is very large and relatively noise-robust. However, the repertoire is a vanishing fraction of all arrangements, while capacity scales only as the sum of the grid periods so field arrangements are constrained over larger distances. Thus, grid-driven place field arrangements define a large response scaffold that is strongly constrained by its structured inputs. Finally, we show that altering grid-place weights to generate an arbitrary new place field strongly affects existing arrangements, which could explain the volatility of the place code.

SUBMITTER: Yim MY

PROVIDER: S-EPMC8294848 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Place-cell capacity and volatility with grid-like inputs.

Yim Man Yi MY Sadun Lorenzo A LA Fiete Ila R IR Taillefumier Thibaud T

eLife 20210524

What factors constrain the arrangement of the multiple fields of a place cell? By modeling place cells as perceptrons that act on multiscale periodic grid-cell inputs, we analytically enumerate a place cell's <i>repertoire</i> - how many field arrangements it can realize without external cues while its grid inputs are unique - and derive its <i>capacity</i> - the spatial range over which it can achieve any field arrangement. We show that the repertoire is very large and relatively noise-robust. ...[more]

PMID: 34028354

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