Heterogeneous long-term trajectories of glycaemic control in type 1 diabetes.

ABSTRACT:

Aims

We aimed to identify long-term HbA1c trajectories and examine associated characteristics in an observational, childhood-onset (<17 years) type 1 diabetes cohort.

Methods

Data are from the Epidemiology of Diabetes Complications study, comprising 405 participants with ≥2 of seven possible HbA1c measurements over follow-up (1988-2013) and available DNA (baseline mean diabetes duration 21 years, 53% men). HbA1c trajectories were estimated using latent class growth models. Baseline and change in participant characteristics were compared across trajectories.

Results

Five HbA1c trajectories were identified: low (51%), intermediate stable (22%), improved (19%), high stable (6%), and worsened (2%; not included in analyses). Age, diabetes duration, diabetes onset age, and

SUBMITTER: Miller RG 

PROVIDER: S-EPMC8295176 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature