Multimodal Elements of Suicidality Reduction After Transcranial Magnetic Stimulation.

ABSTRACT:

Objectives

Repetitive transcranial magnetic stimulation (TMS) is a promising treatment for suicidality, but it is underlying neural mechanisms remain poorly understood. Our prior findings indicated that frontostriatal functional connectivity correlates with the severity of suicidal thoughts and behaviors. In this secondary analysis of data from an open label trial, we evaluated whether changes in frontostriatal functional connectivity would accompany suicidality reductions following TMS. We also explored the relationship between frontostriatal connectivity change and underlying white matter (WM) organization.

Materials and methods

We conducted seed-based functional connectivity analysis on participants (N = 25) with comorbid post-traumatic stress disorder and depression who

SUBMITTER: Barredo J 

PROVIDER: S-EPMC8295183 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature