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Exercise Training Improves Tumor Control by Increasing CD8⁺ T-cell Infiltration via CXCR3 Signaling and Sensitizes Breast Cancer to Immune Checkpoint Blockade.

ABSTRACT: The mechanisms behind the antitumor effects of exercise training (ExTr) are not fully understood. Using mouse models of established breast cancer, we examined here the causal role of CD8⁺ T cells in the benefit acquired from ExTr in tumor control, as well as the ability of ExTr to improve immunotherapy responses. We implanted E0771, EMT6, MMTV-PyMT, and MCa-M3C breast cancer cells orthotopically in wild-type or Cxcr3^-/- female mice and initiated intensity-controlled ExTr sessions when tumors reached approximately 100 mm³ We characterized the tumor microenvironment (TME) using flow cytometry, transcriptome analysis, proteome array, ELISA, and immunohistochemistry. We used antibodies against CD8⁺ T cells for cell depletion. Treatment with im

SUBMITTER: Gomes-Santos IL

PROVIDER: S-EPMC8295193 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Exercise Training Improves Tumor Control by Increasing CD8⁺ T-cell Infiltration via CXCR3 Signaling and Sensitizes Breast Cancer to Immune Checkpoint Blockade.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Exercise Training Improves Tumor Control by Increasing CD8+ T-cell Infiltration via CXCR3 Signaling and Sensitizes Breast Cancer to Immune Checkpoint Blockade.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Exercise Training Improves Tumor Control by Increasing CD8⁺ T-cell Infiltration via CXCR3 Signaling and Sensitizes Breast Cancer to Immune Checkpoint Blockade.