Repeated ethanol intoxications of Drosophila melanogaster adults increases the resistance to ethanol of their progeny.

ABSTRACT:

Background

For decades, Drosophila melanogaster has been used as a model organism to understand the genetics and neurobiology of ethanol intoxication and tolerance. Previous research has shown that acute and chronic pre-exposures to ethanol can trigger the development of functional ethanol tolerance in flies and has unveiled some of the genetic pathways involved in the process. To our knowledge, however, no previous work has systematically explored whether repeated intoxications of adult flies can affect the ethanol tolerance of their progeny.

Methods

Adult flies were intoxicated several times (once daily, over several days), and their F1 and F2 progeny were subjected to a functional tolerance test in which flies are exposed to ethanol and video recorded twice within 5 hr. T

SUBMITTER: Bonilla M 

PROVIDER: S-EPMC8295206 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature