APOE moderates the effect of hippocampal blood flow on memory pattern separation in clinically normal older adults.

ABSTRACT: Pattern separation, the ability to differentiate new information from previously experienced similar information, is highly sensitive to hippocampal structure and function and declines with age. Functional MRI studies have demonstrated hippocampal hyperactivation in older adults compared to young, with greater task-related activation associated with worse pattern separation performance. The current study was designed to determine whether pattern separation was sensitive to differences in task-free hippocampal cerebral blood flow (CBF) in 130 functionally intact older adults. Given prior evidence that apolipoprotein E e4 (APOE e4) status moderates the relationship between CBF and episodic memory, we predicted a stronger negative relationship between hippocampal CBF and pattern separation in

SUBMITTER: Memel M 

PROVIDER: S-EPMC8295213 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature