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Case-control study of hypertension and Parkinson's disease.

ABSTRACT: We evaluate the association of hypertension with PD in an Asian population and performed a meta-analysis on similar studies to address the effect of hypertension on PD risk. A matched case-control study involving 1342 Chinese subjects (671 PD and 671 age and gender-matched controls (with a mean age of 63.9 ± 9.7 and 63.5 ± 9.8 years, and identical proportion of gender distribution) was conducted. Hypertension increases PD risk by 1.9 times [OR 1.86 (1.46-2.38)]. The literature search identified 618 studies initially; however, only three matched case-control studies (all in Caucasians) met the inclusion criteria for meta-analysis. Overall analysis showed that hypertension decreases PD risk by 0.2 times [OR 0.80 (0.66-0.96)]. Hypertension increases PD risk by 1.9 times in our Asian population. However, a meta-analysis comprising of Caucasian populations showed a protective effect of hypertension suggesting that ethnic differences or other genetic or environmental factors may contribute to the divergent observation. Early diagnosis and treatment of hypertension may potentially reduce the risk of PD, at least in our population.

SUBMITTER: Ng YF

PROVIDER: S-EPMC8295270 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Case-control study of hypertension and Parkinson's disease.

Ng Yuen-Fann YF Ng Ebonne E Lim Ee-Wei EW Prakash Kumar M KM Tan Louis C S LCS Tan Eng-King EK

NPJ Parkinson's disease 20210721 1

We evaluate the association of hypertension with PD in an Asian population and performed a meta-analysis on similar studies to address the effect of hypertension on PD risk. A matched case-control study involving 1342 Chinese subjects (671 PD and 671 age and gender-matched controls (with a mean age of 63.9 ± 9.7 and 63.5 ± 9.8 years, and identical proportion of gender distribution) was conducted. Hypertension increases PD risk by 1.9 times [OR 1.86 (1.46-2.38)]. The literature search identified ...[more]

PMID: 34290246

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Project description:ObjectivesLife's essential 8 (LE8) is an emerging approach for accessing and quantifying cardiovascular health (CVH), but the effect on Parkinson's disease (PD) is still unclear. This study aimed to elucidate the association between LE8 metrics and PD in the US adults.MethodsData of 26,975 participants were extracted from the last 7 National Health and Nutrition Examination Survey (NHANES) cycles (2005-2018). The LE8 metrics were calculated according to the American Heart Association criterion, and participants were divided into 3 groups using tertile range. Multivariate logistic regression models were constructed to explore the association between LE8 metrics and PD. Sensitivity analysis was conducted to verify robustness. A nonlinear linkage was evaluated via restricted cubic spline (RCS). The stability of this effect was validated by subgroup analysis and interaction test.ResultsA total of 26,975 eligible participants (including 271 PD cases and 26,704 non-PD cases) were included in this study. The multivariate logistic regression models revealed a reverse association of continuous LE8 metrics with PD with ORs of 0.97 (unadjusted model [95% CI: 0.96-0.98, P < 0.01], partially adjusted model [95% CI: 0.97-0.98, P < 0.01], fully adjusted model [95% CI: 0.95-0.98, P < 0.01]). Compared to those of low group, the ORs for high group were 0.37 (95% CI: 0.27-0.50, P < 0.01) in unadjusted model, 0.51 (95% CI: 0.36-0.72, P < 0.01) in partially adjusted model, and 0.51 (95% CI: 0.32-0.81, P < 0.01) in fully adjusted model. The sensitivity analysis ensured the robustness of the observed LE8-PD association. A nonlinear relationship (P nonlinearity < 0.01) was observed via RCS analysis. The subgroup analysis showed that participants'gender might impact the strength of LE8 metrics-PD association (P interaction = 0.029).ConclusionsCVH, as delineated by LE8 metrics, was reversely associated with PD in the dose-response pattern, more pronounced in female compared to male. These findings highlight the potential of the LE8 metrics to guide targeted strategies for addressing gender-based CVH disparities, offering beneficial insights for the tertiary prevention of PD.

Dataset Information

Case-control study of hypertension and Parkinson's disease.

Publications

Case-control study of hypertension and Parkinson's disease.

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