Associations between lipids in selected brain regions, plasma miRNA, and behavioral and cognitive measures following ²⁸Si ion irradiation.

ABSTRACT: The space radiation environment consists of multiple species of charged particles, including ²⁸Si ions, that may impact brain function during and following missions. To develop biomarkers of the space radiation response, BALB/c and C3H female and male mice and their F2 hybrid progeny were irradiated with ²⁸Si ions (350 MeV/n, 0.2 Gy) and tested for behavioral and cognitive performance 1, 6, and 12 months following irradiation. The plasma of the mice was collected for analysis of miRNA levels. Select pertinent brain regions were dissected for lipidomic analyses and analyses of levels of select biomarkers shown to be sensitive to effects of space radiation in previous studies. There were associations between lipids in select brain regions, plasma miRNA, and cognitive me

SUBMITTER: Minnier J 

PROVIDER: S-EPMC8295277 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature