Dataset Information

Immune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in mice.

ABSTRACT: The immune system plays a role in the maintenance of healthy neurocognitive function. Different patterns of immune response triggered by distinct stimuli may affect nervous functions through regulatory or deregulatory signals, depending on the properties of the exogenous immunogens. Here, we investigate the effect of immune stimulation on cognitive-behavioural parameters in healthy mice and its impact on cognitive sequelae resulting from non-severe experimental malaria. We show that immune modulation induced by a specific combination of immune stimuli that induce a type 2 immune response can enhance long-term recognition memory in healthy adult mice subjected to novel object recognition task (NORT) and reverse a lack of recognition ability in NORT and anxiety-like behaviour in a light/dark task that result from a single episode of mild Plasmodium berghei ANKA malaria. Our findings suggest a potential use of immunogens for boosting and recovering recognition memory that may be impaired by chronic and infectious diseases and by the effects of ageing.

SUBMITTER: de Sousa LP

PROVIDER: S-EPMC8295320 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Immune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in mice.

de Sousa Luciana Pereira LP Ribeiro-Gomes Flávia Lima FL de Almeida Roberto Farina RF Souza Tadeu Mello E TME Werneck Guilherme Loureiro GL Souza Diogo Onofre DO Daniel-Ribeiro Cláudio Tadeu CT

Scientific reports 20210721 1

The immune system plays a role in the maintenance of healthy neurocognitive function. Different patterns of immune response triggered by distinct stimuli may affect nervous functions through regulatory or deregulatory signals, depending on the properties of the exogenous immunogens. Here, we investigate the effect of immune stimulation on cognitive-behavioural parameters in healthy mice and its impact on cognitive sequelae resulting from non-severe experimental malaria. We show that immune modul ...[more]

PMID: 34290279

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Project description:ObjectivesVascular cognitive impairment is the second most common type of cognitive impairment. Care needs of community-dwelling people with vascular cognitive impairment and their caregivers have not been thoroughly studied. Therefore, we aimed to explore care needs of people with vascular cognitive impairment and their family caregivers.DesignA qualitative interview study.Setting and participantsParticipants were purposefully sampled community-dwelling people with vascular cognitive impairment and their family caregivers.MethodsInterviews were audiotaped and transcribed verbatim. Analysis and data collection followed an iterative process, until data saturation was achieved. We conducted 18 interviews (nine people with vascular cognitive impairment and nine caregivers), concerning 13 unique people with vascular cognitive impairment. We analyzed the data using inductive thematic analysis following the Braun & Clark method. The study was reported in accordance with the COREQ criteria.FindingsFive themes were identified in the care needs reported by people with vascular cognitive impairment and family caregivers: (1) Specific information need with subtheme (1A) No memory problem, no dementia? (2) Being respected as a person, (3) Differing concerns about the future, (4) The roles of the caregiver and (5) Decisiveness from professional healthcare.Conclusions and implicationsThe care needs of people with vascular cognitive impairment and their caregivers were affected by (a lack of knowledge about) the characteristic symptoms of this condition. Participants equated cognitive impairment or dementia to memory loss ("Alzheimerization"), although memory loss was not their biggest challenge. People with vascular cognitive impairment and caregivers preferred resolute and decisive healthcare professionals. These professionals activate the person with vascular cognitive impairment who lacks initiative and diminishe role conflict of the caregiver. Care for people with vascular cognitive impairment and their caregivers could be improved by providing tailored information, promoting awareness of neuropsychiatric symptoms, particularly apathy, and by healthcare professionals providing more guidance in decision-making.

Dataset Information

Immune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in mice.

Publications

Immune system challenge improves recognition memory and reverses malaria-induced cognitive impairment in mice.

Similar Datasets

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