Ontology highlight
ABSTRACT:
SUBMITTER: Methatham T
PROVIDER: S-EPMC8295328 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Methatham Thanachai T Tomida Shota S Kimura Natsuka N Imai Yasushi Y Aizawa Kenichi K
Scientific reports 20210721 1
In heart failure (HF) caused by hypertension, the myocyte size increases, and the cardiac wall thickens. A low-molecular-weight compound called ICG001 impedes β-catenin-mediated gene transcription, thereby protecting both the heart and kidney. However, the HF-preventive mechanisms of ICG001 remain unclear. Hence, we investigated how ICG001 can prevent cardiac hypertrophy and fibrosis induced by transverse aortic constriction (TAC). Four weeks after TAC, ICG001 attenuated cardiac hypertrophy and ...[more]