Placebo-controlled trial of bupropion for smoking cessation in pregnant women.

ABSTRACT:

Background

Although a relatively small proportion of women who become pregnant continue to smoke cigarettes, no smoking cessation medication has been shown to be effective for this subgroup of smokers. Bupropion, a nonnicotine-based medication, is approved for the promotion of smoking cessation in nonpregnant individuals. We chose to study it in pregnant smokers because, although pregnancy increases nicotine metabolism, it does not affect the metabolism of bupropion.

Objective

We evaluated the efficacy and safety of sustained-release bupropion for smoking cessation among pregnant women.

Study design

We conducted a multiple site, placebo-controlled, randomized clinical trial of bupropion for tobacco use among pregnant women (N=129) (clinical trial number NCT02188459).

SUBMITTER: Kranzler HR 

PROVIDER: S-EPMC8295398 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature