SARS-CoV-2 attenuates corticosteroid sensitivity by suppressing DUSP1 expression and activating p38 MAPK pathway.
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ABSTRACT:
SUBMITTER: Saheb Sharif-Askari F
PROVIDER: S-EPMC8295491 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
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SARS-CoV-2 attenuates corticosteroid sensitivity by suppressing DUSP1 expression and activating p38 MAPK pathway.
Saheb Sharif-Askari Fatemeh F Saheb Sharif-Askari Narjes N Goel Swati S Hafezi Shirin S Assiri Rasha R Al-Muhsen Saleh S Hamid Qutayba Q Halwani Rabih R
European journal of pharmacology 20210722
The efficacy of corticosteroids and its use for the treatment of SARS-CoV-2 infections is controversial. In this study, using data sets of SARS-CoV-2 infected lung tissues and nasopharyngeal swabs, as well as in vitro experiments, we show that SARS-CoV-2 infection significantly downregulates DUSP1 expression. This downregulation of DUSP1 could be the mechanism regulating the enhanced activation of MAPK pathway as well as the reported steroid resistance in SARS-CoV-2 infection. Moreover, chloroqu ...[more]
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