Monocytes in sarcoidosis are potent tumour necrosis factor producers and predict disease outcome.

ABSTRACT:

Background

Pulmonary sarcoidosis is an inflammatory disease characterised by granuloma formation and heterogeneous clinical outcome. Tumour necrosis factor (TNF) is a pro-inflammatory cytokine contributing to granuloma formation and high levels of TNF have been shown to associate with progressive disease. Mononuclear phagocytes (MNPs) are potent producers of TNF and highly responsive to inflammation. In sarcoidosis, alveolar macrophages have been well studied. However, MNPs also include monocytes/monocyte-derived cells and dendritic cells, which are poorly studied in sarcoidosis, despite their central role in inflammation.

Objective

To determine the role of pulmonary monocyte-derived cells and dendritic cells during sarcoidosis.

Methods

We performed in-depth phenotypi

SUBMITTER: Lepzien R 

PROVIDER: S-EPMC8295505 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature