Hepatic lead and copper concentrations in dogs with chronic hepatitis and their relationship with hematology, serum biochemistry, and histopathology.

ABSTRACT:

Background

Although the influence of copper ([Cu]) on chronic hepatitis (CH) has been widely studied in dogs, little information is available about the accumulation of other metals.

Hypothesis/objectives

We assessed the concentration of lead ([Pb]) in the livers of dogs with CH with or without abnormal hepatic [Cu] to establish if any association existed between [Pb] and either hematologic or biochemical variables, fibrosis, necrosis and inflammation of the liver on histology.

Animals

Thirty-four dogs with CH that had hepatic [Cu] and [Pb] determined.

Methods

Retrospective review of medical records of dogs with CH and hepatic [Cu] and [Pb]. Chronic hepatitis was defined using current American College of Veterinary Internal Medicine consensus statement guideline

SUBMITTER: Gori E 

PROVIDER: S-EPMC8295653 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature