Embedded Microbubbles for Acoustic Manipulation of Single Cells and Microfluidic Applications.

ABSTRACT: Acoustically excited microstructures have demonstrated significant potential for small-scale biomedical applications by overcoming major microfluidic limitations. Recently, the application of oscillating microbubbles has demonstrated their superiority over acoustically excited solid structures due to their enhanced acoustic streaming at low input power. However, their limited temporal stability hinders their direct applicability for industrial or clinical purposes. Here, we introduce the embedded microbubble, a novel acoustofluidic design based on the combination of solid structures (poly(dimethylsiloxane)) and microbubbles (air-filled cavity) to combine the benefits of both approaches while minimizing their drawbacks. We investigate the influence of various design parameters and geometric

SUBMITTER: Laubli NF 

PROVIDER: S-EPMC8295982 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature