Long-term changes in hepatic fibrosis following hepatitis C viral clearance in patients with and without HIV.

ABSTRACT:

Background

While acute changes in hepatic fibrosis are recognized shortly after achieving sustained virological response (SVR) using direct-acting antiviral therapies, long-term outcomes for the growing population of successfully treated patients with HCV remain uncertain. The aim of this study is to characterize long-term changes in fibrosis following SVR in patients with and without HIV and to identify potential factors associated with progression or regression of fibrosis.

Methods

We completed a prospective longitudinal study of 162 subjects with HCV (34% HIV-coinfected) with pre-treatment fibrosis stage determined by liver biopsy and post-SVR transient elastography. Progression of fibrosis was defined as a two-stage or greater increase in fibrosis, while regression was d

SUBMITTER: Balmaceda JB 

PROVIDER: S-EPMC8296308 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature