Ontology highlight
ABSTRACT:
SUBMITTER: Valentino H
PROVIDER: S-EPMC8296543 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Valentino Hannah H Korasick David A DA Bohac Tabbetha J TJ Shapiro Justin A JA Wencewicz Timothy A TA Tanner John J JJ Sobrado Pablo P
ACS omega 20210706 28
<i>Acinetobacter baumannii</i> is an opportunistic pathogen with a high mortality rate due to multi-drug-resistant strains. The synthesis and uptake of the iron-chelating siderophores acinetobactin (Acb) and preacinetobactin (pre-Acb) have been shown to be essential for virulence. Here, we report the kinetic and structural characterization of BauF, a flavin-dependent siderophore-interacting protein (SIP) required for the reduction of Fe(III) bound to Acb/pre-Acb and release of Fe(II). Stopped-fl ...[more]