Genomics and transcriptomics yields a system-level view of the biology of the pathogen Naegleria fowleri.

ABSTRACT:

Background

The opportunistic pathogen Naegleria fowleri establishes infection in the human brain, killing almost invariably within 2 weeks. The amoeba performs piece-meal ingestion, or trogocytosis, of brain material causing direct tissue damage and massive inflammation. The cellular basis distinguishing N. fowleri from other Naegleria species, which are all non-pathogenic, is not known. Yet, with the geographic range of N. fowleri advancing, potentially due to climate change, understanding how this pathogen invades and kills is both important and timely.

Results

Here, we report an -omics approach to understanding N. fowleri biology and infection at the system level. We sequenced two new strains of N. fowleri and performed a transcriptomic analysis of low- versus high-pathog

SUBMITTER: Herman EK 

PROVIDER: S-EPMC8296547 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature