Putative mobilized colistin resistance genes in the human gut microbiome.

ABSTRACT:

Background

The high incidence of bacterial genes that confer resistance to last-resort antibiotics, such as colistin, caused by mobilized colistin resistance (mcr) genes, poses an unprecedented threat to human health. Understanding the spread, evolution, and distribution of such genes among human populations will help in the development of strategies to diminish their occurrence. To tackle this problem, we investigated the distribution and prevalence of potential mcr genes in the human gut microbiome using a set of bioinformatics tools to screen the Unified Human Gastrointestinal Genome (UHGG) collection for the presence, synteny and phylogeny of putative mcr genes, and co-located antibiotic resistance genes.

Results

A total of 2079 antibiotic resistance genes (ARGs) were cl

SUBMITTER: Andrade BGN 

PROVIDER: S-EPMC8296556 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature