Construct validity of the OCTOPuS stratification algorithm for allocating patients with knee osteoarthritis into subgroups.

ABSTRACT:

Background

We recently developed a model of stratified exercise therapy, consisting of (i) a stratification algorithm allocating patients with knee osteoarthritis (OA) into one of the three subgroups ('high muscle strength subgroup' representing a post-traumatic phenotype, 'low muscle strength subgroup' representing an age-induced phenotype, and 'obesity subgroup' representing a metabolic phenotype) and (ii) subgroup-specific exercise therapy. In the present study, we aimed to test the construct validity of this algorithm.

Methods

Data from five studies (four exercise therapy trial cohorts and one cross-sectional cohort) were used to test the construct validity of our algorithm by 63 a priori formulated hypotheses regarding three research questions: (i) are the proportions o

SUBMITTER: Knoop J 

PROVIDER: S-EPMC8296670 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature