Identification of molecular biomarkers associated with disease progression in the testis of bulls infected with Besnoitia besnoiti.

ABSTRACT: Breeding bulls infected with Besnoitia besnoiti may develop sterility during either acute or chronic infection. The aim of this study was to investigate the molecular pathogenesis of B. besnoiti infection with prognosis value in bull sterility. Accordingly, five well-characterized groups of naturally and experimentally infected males were selected for the study based on clinical signs and lesions compatible with B. besnoiti infection, serological results and parasite detection. A broad panel of molecular markers representative of endothelial activation and fibrosis was investigated and complemented with a histopathological approach that included conventional histology and immunohistochemistry. The results indicated the predominance of an intense inflammatory infiltrate composed mainly of r

SUBMITTER: Gonzalez-Barrio D 

PROVIDER: S-EPMC8296687 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature