Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study.

ABSTRACT:

Background

Observational studies show an association between reduced lung function and impaired cognition. Cognitive dysfunction influences important health outcomes and is a precursor to dementia, but treatments options are currently very limited. Attention has therefore focused on identifying modifiable risk factors to prevent cognitive decline and preserve cognition. Our objective was to determine if lung function or risk of COPD causes reduced cognitive function using Mendelian randomization (MR).

Methods

Single nucleotide polymorphisms from genome wide association studies of lung function and COPD were used as exposures. We examined their effect on general cognitive function in a sample of 132,452 individuals. We then performed multivariable MR (MVMR), examining the eff

SUBMITTER: Higbee DH 

PROVIDER: S-EPMC8296721 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature