Frequent Genetic Alterations and Their Clinical Significance in Patients With Thymic Epithelial Tumors.

ABSTRACT:

Purpose

Thymic epithelial tumors (TETs) are relatively rare neoplasms, including thymomas (types A, AB, B1, B2, and B3) and thymic carcinomas (TCs). The current knowledge about the biological properties of TETs is limited due to their low incidence. This study aimed to detect genetic alterations in TETs using next-generation sequencing(NGS) and explore their clinical significance in survival.

Methods

Tumor tissues and clinical data were collected from 34 patients with resected TETs in the Tianjin Medical University General Hospital between January 2011 and January 2019, and 56 cancer-associated genes were analyzed. The data of 123 TETs were retrieved from TCGA, and the information on their clinical and somatic mutations was explored.

Results

The cohort comprised 34 TE

SUBMITTER: Xu S 

PROVIDER: S-EPMC8296820 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature