Epigenome-wide analysis uncovers a blood-based DNA methylation biomarker of lifetime cannabis use.

ABSTRACT: Cannabis use is highly prevalent and is associated with adverse and beneficial effects. To better understand the full spectrum of health consequences, biomarkers that accurately classify cannabis use are needed. DNA methylation (DNAm) is an excellent candidate, yet no blood-based epigenome-wide association studies (EWAS) in humans exist. We conducted an EWAS of lifetime cannabis use (ever vs. never) using blood-based DNAm data from a case-cohort study within Sister Study, a prospective cohort of women at risk of developing breast cancer (Discovery N = 1,730 [855 ever users]; Replication N = 853 [392 ever users]). We identified and replicated an association with lifetime cannabis use at cg15973234 (CEMIP): combined p = 3.3 × 10^-8 . We found no overlap between published blood-base

SUBMITTER: Markunas CA 

PROVIDER: S-EPMC8296847 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature