An Assessment on Ethanol-Blended Gasoline/Diesel Fuels on Cancer Risk and Mortality.

ABSTRACT: Although cancer is traditionally considered a genetic disease, the epigenetic abnormalities, including DNA hypermethylation, histone deacetylation, and/or microRNA dysregulation, have been demonstrated as a hallmark of cancer. Compared with gene mutations, aberrant epigenetic changes occur more frequently, and cellular epigenome is more susceptible to change by environmental factors. Excess cancer risks are positively associated with exposure to occupational and environmental chemical carcinogens, including those from gasoline combustion exhausted in vehicles. Of note, previous studies proposed particulate matter index (PMI) as a measure for gasoline sooting tendency, and showed that, compared with the other molecules in gasoline, 1,2,4-Trimethylbenzene, 2-methylnaphthalene and toluene sig

SUBMITTER: Mueller S 

PROVIDER: S-EPMC8297295 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature