Causal Associations of Urate With Cardiovascular Risk Factors: Two-Sample Mendelian Randomization.

ABSTRACT:

Background

Mendelian Randomization (MR) studies show conflicting causal associations of genetically predicted serum urate with cardiovascular risk factors (i.e., hypertension, diabetes, lipid profile, and kidney function). This study aimed to robustly investigate a causal relationship between urate and cardiovascular risk factors considering single nucleotide polymorphisms (SNPs) as instrumental variables using two-sample MR and various sensitivity analyses.

Methods

Data on SNP-urate associations were taken from the Global Urate Genetics Consortium and data on SNP-cardiovascular risk factor associations were taken from various consortia/UK Biobank. SNPs were selected by statistically and biologically driven approaches as instrumental variables. Various sensitivity analyses w

SUBMITTER: Lukkunaprasit T 

PROVIDER: S-EPMC8297413 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature